abstract：OBJECTIVES:The aim of the study was to estimate the frequency of ABCB4 mutations among children with chronic intrahepatic cholestasis with elevated gamma-glutamyl-transpeptidase (γ-GT) activity and to characterize the genotypes with respect to severity of symptoms, response to ursodeoxycholic acid therapy, and outcome....

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Colombo C,Vajro P,Degiorgio D,Coviello DA,Costantino L,Tornillo L,Motta V,Consonni D,Maggiore G,SIGENP Study Group for Genetic Cholestasis.

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Although direct medical costs for constipation-related medical visits are thought to be high, to date there have been no studies examining whether longitudinal resource use is persistently elevated in children with constipation. Our aim was to estimate the incremental direct medical costs and types of health...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Choung RS,Shah ND,Chitkara D,Branda ME,Van Tilburg MA,Whitehead WE,Katusic SK,Locke GR 3rd,Talley NJ

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to evaluate erosive esophagitis healing and symptom improvement with once-daily esomeprazole in children ages 12 to 36 months with endoscopically or histologically proven gastroesophageal reflux disease (GERD). PATIENTS AND METHODS:Data from children ages 12 to 36 months were includ...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Tolia V,Gilger MA,Barker PN,Illueca M

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVES:The aim of this review was to examine the characteristics of the faecal calprotectin assay in neonates and the evidence for its use as a noninvasive marker of intestinal illnesses during the neonatal period. METHODS:Bibliographic searches were performed in the MEDLINE electronic database up to February 2010...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Kapel N,Campeotto F,Kalach N,Baldassare M,Butel MJ,Dupont C

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Eosinophilic esophagitis (EoE) is an allergic disease of the esophagus. The IgE receptors on immune cells that infiltrate the esophagus are poorly defined. The high-affinity receptor for IgE, FcεRI, may play a role in EoE. The objective of the present study is to identify and compare the IgE re...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Yen EH,Hornick JL,Dehlink E,Dokter M,Baker A,Fiebiger E,Nurko S

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:The small bowel follow-through (SBFT) is a noninvasive imaging modality for evaluating terminal ileum (TI) inflammation. The accuracy of this modality in pediatric patients is not well established. PATIENTS AND METHODS:We retrospectively determined the sensitivity and specificity of SBFT for detecting TI in...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Stenerson M,Vittinghoff E,Heyman MB,Kim GE,Gupta N

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:Eosinophilic oesophagitis (EE) is a clinical entity characterised by a set of symptoms and eosinophilic infiltration of the oesophageal epithelium. Recent reports indicate that EE is increasingly diagnosed in paediatric patients. We aimed to evaluate the epidemiology of paediatric EE in a European population....

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Dalby K,Nielsen RG,Kruse-Andersen S,Fenger C,Bindslev-Jensen C,Ljungberg S,Larsen K,Walsted AM,Husby S

更新日期：2010-09-01 00:00:00

abstract：:Colonoscopy is a routinely performed procedure in children and adolescents. Proper visualization of the intestinal mucosa, completion of the procedure, including examination of the terminal ileum, detection of pathological lesions, and therapeutic maneuvers, all are highly dependent on the quality of the bowel prepara...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Hunter A,Mamula P

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Many patients with chronic hepatitis C do not respond to antiviral treatment. In adult patients the re-treatment of these patients has been extensively investigated. Because the response to re-treatment in children is not well defined we evaluated the efficacy and safety of interferon (IFN)-alpha plus ribavi...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Gerner P,Hilbich J,Wenzl TG,Behrens R,Walther F,Kliemann G,Enninger A,Wirth S

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVES:Early amino acid administration has been recommended in preterm neonates to avoid protein catabolism. In the present work, blood urea nitrogen (BUN) was used to evaluate the quantity of protein intake in preterm infants. The aim of the study was to investigate the relation between protein intake and BUN duri...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Roggero P,Giannì ML,Morlacchi L,Piemontese P,Liotto N,Taroni F,Mosca F

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:In patients with biliary atresia (BA), liver fibrosis and cirrhosis commonly occur even after Kasai hepatoportoenterostomy. Although liver biopsy is the gold standard to evaluate liver fibrosis, it is invasive and may result in life-threatening complications. The aspartate aminotransferase-to-platelet ratio ...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Kim SY,Seok JY,Han SJ,Koh H

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:There are no available data for outcomes in children's idiopathic superior mesenteric artery syndrome (SMAS) strictly treated conservatively. The aim of the study was to evaluate clinical and nutritional outcome in children with idiopathic SMAS. PATIENTS AND METHODS:A 1-year prospective observation study of ...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Shiu JR,Chao HC,Luo CC,Lai MW,Kong MS,Chen SY,Chen CC,Wang CJ

更新日期：2010-08-01 00:00:00

abstract：:Enteral nutrition support (ENS) involves both the delivery of nutrients via feeding tubes and the provision of specialised oral nutritional supplements. ENS is indicated in a patient with at least a partially functioning digestive tract when oral intake is inadequate or intake of normal food is inappropriate to meet t...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Braegger C,Decsi T,Dias JA,Hartman C,Kolacek S,Koletzko B,Koletzko S,Mihatsch W,Moreno L,Puntis J,Shamir R,Szajewska H,Turck D,van Goudoever J,ESPGHAN Committee on Nutrition:.

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVES:: Several serologic assays are commercially available to aid in the diagnosis of gluten-sensitive enteropathy (GSE). Our objective in this study was to assess the performance of a novel combined antigen-screening assay for GSE. PATIENTS AND METHODS:: Deidentified sera from 111 pediatric patients suspected o...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Jaskowski TD,Donaldson MR,Hull CM,Wilson AR,Hill HR,Zone JJ,Book LS

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVES:: Biliary atresia (BA) is a leading cause of end-stage paediatric liver disease. Standard BA treatment is sequential surgery with an initial Kasai procedure (KP) followed by liver transplant (LT) for patients who progress to liver failure. A key determinant for the post-KP patient survival with their native ...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Schreiber RA,Barker CC,Roberts EA,Martin SR,Canadian Pediatric Hepatology Research Group.

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVES:Congenital hepatic fibrosis (CHF) is an important cause of morbidity and mortality in patients with autosomal recessive polycystic kidney disease (ARPKD). The pathogenesis of CHF remains undefined. Several recent studies suggest that the renin-angiotensin system (RAS) is an important mediator of progressive ...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Goto M,Hoxha N,Osman R,Wen J,Wells RG,Dell KM

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVES:Zinc (Zn) homeostasis in adults is achieved principally through a balance between intestinal absorption and excretion involving adaptive mechanisms programmed by levels of dietary Zn. Zn absorption in infants is not as tightly regulated as that in adults, which may induce potential toxicity in infants due to...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Jou MY,Philipps AF,Kelleher SL,Lönnerdal B

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to design a theory-based educational program for adolescents with inflammatory bowel disease (IBD) using an interactive multimedia CD-ROM and to test its effectiveness in improving knowledge in IBD. MATERIALS AND METHODS:Curriculum-based instruction using educational theory and prin...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Boamah LM,Bohren JR,Pentiuk S,Baker R,Yi M,Moyer MS

更新日期：2010-05-01 00:00:00

abstract：AIM AND OBJECTIVE:: Chronic models of inflammatory bowel disease are lacking in preadult rodents. The primary goal of our study was to develop a chronic model of hapten-induced intestinal inflammation and fibrosis in young rats. Second, we aimed to determine the profiles of key Th-1, Th-2, and Th-17 proinflammatory and...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Fitzpatrick LR,Meirelles K,Small JS,Puleo FJ,Koltun WA,Cooney RN

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Total esophagogastric dissociation (TED) was first described in 1997 by Bianchi as a new surgical procedure to treat severe gastroesophageal reflux disease (GERD) in children with neurological impairment. Recently, TED has been proposed in other conditions, such as esophageal atresia, esotracheal cleft, or c...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Madre C,Serhal L,Michaud L,Bonnevalle M,de Lagausie P,Gottrand F,Bonnard A,Hugot JP

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND AND AIM:Gastroduodenal disease is more common among adults and children with cagA+ Helicobacter pylori infection, but disease severity varies among those infected with cagA+ strains. We examined whether cagA in situ expression can predict disease manifestations among H pylori-infected children. PATIENTS AND...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Rick JR,Goldman M,Semino-Mora C,Liu H,Olsen C,Rueda-Pedraza E,Sullivan C,Dubois A

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVES:Little is known about the practice of introducing complementary feeding across Europe. We aim at describing times of solid introduction in healthy infants in 5 European countries. MATERIALS AND METHODS:Between October 2002 and June 2004, 1678 healthy term infants were either breast-fed (BF) for at least 4 m...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Schiess S,Grote V,Scaglioni S,Luque V,Martin F,Stolarczyk A,Vecchi F,Koletzko B,European Childhood Obesity Project.

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:Data suggest an increase in the incidence of pediatric inflammatory bowel disease (IBD). We examined the trend of the incidence of IBD in children. PATIENTS AND METHODS:A retrospective investigation was conducted on a cohort of children diagnosed with IBD between 1991 and 2002 who were registered in the IBD ...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Malaty HM,Fan X,Opekun AR,Thibodeaux C,Ferry GD

更新日期：2010-01-01 00:00:00

abstract：:The number of surviving children born prematurely has increased substantially during the last 2 decades. The major goal of enteral nutrient supply to these infants is to achieve growth similar to foetal growth coupled with satisfactory functional development. The accumulation of knowledge since the previous guideline ...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Agostoni C,Buonocore G,Carnielli VP,De Curtis M,Darmaun D,Decsi T,Domellöf M,Embleton ND,Fusch C,Genzel-Boroviczeny O,Goulet O,Kalhan SC,Kolacek S,Koletzko B,Lapillonne A,Mihatsch W,Moreno L,Neu J,Poindexter B,Punti

更新日期：2010-01-01 00:00:00

abstract：:The relation between Crohn disease (CD) and mycobacterial infection is complex and intriguing. The 2 conditions share common immunopathogenic features, and the hypothesis that Mycobacterium avium subspecies paratuberculosis may cause CD is still under debate. Moreover, differential diagnosis between CD and intestinal ...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Chiappini E,de Martino M,Mangiantini F,Lionetti P

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVES:: Given dietary gluten exposure, growing children with celiac disease may experience malabsorption of nutrients, negatively affecting bone health. The purpose of this study was to determine the prevalence of low bone mass in children with celiac disease, according to the presence of symptoms at diagnosis. M...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Turner J,Pellerin G,Mager D

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVES:Pancreatitis is a known complication of endoscopic retrograde cholangiopancreatography (ERCP). Our aim was to assess the prevalence and severity of ERCP-associated pancreatitis using established criteria. MATERIALS AND METHODS:Retrospective review of patients younger than 18 years undergoing ERCP complicate...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Iqbal CW,Baron TH,Moir CR,Ishitani MB

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Although infection with Helicobacter pylori in children mostly induces asymptomatic chronic gastritis, the clinical outcome of H pylori infection is generally unpredictable. To identify the risk subgroup of infected children who can progress toward serious gastrointestinal disease, we assessed the prevalence...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Homan M,Luzar B,Kocjan BJ,Orel R,Mocilnik T,Shrestha M,Kveder M,Poljak M

更新日期：2009-09-01 00:00:00

abstract：:The Institute of Medicine's publications To Error is Human and Crossing the Quality Chasm publicized the widespread deficits in US health care quality. Emerging studies continue to reveal deficits in the quality of adult and pediatric care, including subspecialty care. In recent years, key stakeholders in the health c...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Boyle BM,Palmer L,Kappelman MD

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVES:Diarrheal diseases remain a major human plague that still claim millions of lives every year. Probiotics, including Lactobacillus GG (LGG), are known to have a beneficial effect on diarrheal diseases, but their mechanism of action has not yet been completely established. Therefore, the main objective of this...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Lu R,Fasano S,Madayiputhiya N,Morin NP,Nataro J,Fasano A

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:Studies in adults characterized the role of the pregnane X receptor (PXR) in the pathophysiology of inflammatory bowel disease (IBD) with conflicting results; pediatric studies are still lacking. PATIENTS AND METHODS:Genotyping for the -25385C/T polymorphism of the PXR gene in 187 white children with IBD and...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Lacher M,Kappler R,Schroepf S,Berkholz S,Ballauff A,Bufler P,Baurecht H,von Schweinitz D,Koletzko S

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVES:Information on epithelial functions of the residual small or colonic bowel after resection for necrotising enterocolitis (NEC) in human infants is scarce. Our aim is to evaluate epithelial functions in the intestinal resection margins of tissue obtained at bowel resection for acute NEC and consecutive stoma ...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Schaart MW,de Bruijn AC,Bouwman DM,de Krijger RR,van Goudoever JB,Tibboel D,Renes IB

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:To investigate and compare the effects of enteral glutamine and arginine supply on lipid peroxidation and antioxidant enzyme levels in the small intestine of healthy breast-fed rats. MATERIALS AND METHODS:The study comprised 40 newborn Sprague-Dawley rats born to 5 mother rats. Newborn rats were randomly div...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Kul M,Vurucu S,Demirkaya E,Tunc T,Aydinoz S,Meral C,Kesik V,Alpay F

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVES:Accurate tube placement of orogastric and nasogastric feeding tubes in neonates is important to ensure safe and effective enteral feeding. Errors in placement and position of feeding tubes are described in literature, but there is little evidence of the exact prevalence of improperly placed tubes, especially...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Quandt D,Schraner T,Ulrich Bucher H,Arlettaz Mieth R

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to investigate the in vitro effects of sera from children with acute liver failure (ALF) who had received N-acetylcysteine (NAC) on the metabolic and synthetic activity of cryopreserved human hepatocytes. MATERIALS AND METHODS:Cryopreserved human hepatocytes were plated on collagen-c...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Mitry RR,Bansal S,Hughes RD,Mieli-Vergani G,Dhawan A

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVES:Twenty-four-hour pH-metry represents the gold standard for the diagnosis of gastroesophageal reflux. Ambulatory esophageal pH recording provides a better reflection of occurrences under normal domestic living conditions, but it may influence physical activity. The aim of this study was to assess the influenc...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Michaud L,Troadec F,Béghin L,El Rifai N,Guimber D,Turck D,Gottrand F

更新日期：2009-04-01 00:00:00

abstract：:Chronic constipation is one of the most frequent complaints in childhood. Although there is evidence that gastrointestinal flora is important in gut motility, there is little evidence that gut flora is abnormal in constipation. Lactobacilli and bifidobacteria increase stool frequency and decrease consistency in normal...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Vandenplas Y,Benninga M

更新日期：2009-04-01 00:00:00

abstract：:Colon is a crucial partner for small intestinal adaptation and function in patients who underwent extensive small intestinal resection or transplantation. This short review deals with the different properties and roles of the colon in these settings, involving fluid and electrolytes absorption, absorption of medium-ch...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Goulet O,Colomb-Jung V,Joly F

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:An increased incidence of necrotizing enterocolitis (NEC) has been noted in infants who are born to mothers with chorioamnionitis. HYPOTHESIS:Our objective was to test the hypothesis that newborn rat pups born to mothers exposed to prenatal lipopolysaccharide during pregnancy would be more susceptible to in...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Giannone PJ,Nankervis CA,Richter JM,Schanbacher BL,Reber KM

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:Selected infants with short bowel syndrome (SBS) and progressive intestinal failure associated liver disease (IFALD) may benefit from isolated liver transplantation (iLTx). The aim of the study is to identify risk factors for unfavourable outcome in iLTx. PATIENTS AND METHODS:A retrospective review of medica...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Dell-Olio D,Beath SV,de Ville de Goyet J,Clarke S,Davies P,Lloyd C,Protheroe S,Millar AJ,Kelly DA,Gupte GL

更新日期：2009-03-01 00:00:00